High Incidence of Severe Parasitemia in Falciparum Malaria
نویسندگان
چکیده
منابع مشابه
Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia
BACKGROUND Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. METHODS Fifty-six adult patients with severe malaria and...
متن کاملVAR2CSA Signatures of High Plasmodium falciparum Parasitemia in the Placenta
Plasmodium falciparum infected erythrocytes (IE) accumulate in the placenta through the interaction between Duffy-binding like (DBL) domains of parasite-encoded ligand VAR2CSA and chondroitin sulphate-A (CSA) receptor. Polymorphisms in these domains, including DBL2X and DBL3X, may affect their antigenicity or CSA-binding affinity, eventually increasing parasitemia and its adverse effects on pre...
متن کاملSevere haemophagocytic syndrome in falciparum malaria.
Malaria is responsible for 0.5-1.2 million deaths each year. The majority of fatal cases are due to Plasmodium falciparum infection which is known for its severity, complications and drug resistance. Most of the fatalities occur in children and nonimmune travellers to the endemic areas. A number of complications have been described in falciparum malaria but, to the best of our knowledge, haemop...
متن کاملMicrovascular dysfunction in severe Plasmodium falciparum Malaria.
TO THE EDITOR—Hanson and colleagues present a commendable attempt to determine the relative contribution of macrovascular and microvascular dysfunction in severe Plasmodium falciparum malaria [1]. The number of capillaries with impaired flow correlated with the severity of illness and central venous lactate, whereas most indices of macrovascular function did not [1]. Thus, this study demonstrat...
متن کاملPrognostic Factors in Severe Falciparum Malaria
Polrat Wilairatana1,2*, Noppadon Tangpukdee1,2 and Srivicha Krudsood1,3 1Malaria Clinical Research Unit, Malaria Excellence Center, Mahidol University, Thailand 2Department of Clinical Tropical Medicine, Mahidol University, Thailand 3Department of Tropical Hygiene, Mahidol University, Thailand *Corresponding author: Polrat Wilairatana, Malaria Clinical Research Unit, Malaria Excellence Center a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Journal Armed Forces India
سال: 2002
ISSN: 0377-1237
DOI: 10.1016/s0377-1237(02)80073-9